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Thiocol
Potassium Guaiacol Sulphonate
IUPAC Name: potassium 2-(hydroxymethoxy)benzenesulfonate | CAS Registry
Number: 1321-14-8
Synonyms: Sulfogaiacol, Sirokol, Thiocol, Silborina sirup, Kalium sulfaguajakol, potassium guaiacolsulfonate, Sulfogaiacol (INN), Kalium sulfoguajacolicum, Solfoguaiacolo [DCIT], Kalium guaiacolsulfonicum, Potassium guaiacolsufonate, Guajakolsulfonsaeure kalium, Sulfogaiacolum [INN-Latin], Sulfoguayacol [INN-Spanish], Potassium guaiacolsulfonate hydrate, Potassium guaiacolsulfonate (USAN), Potassium Guaiacolsulfonate [USAN], Potassium guaiacolsulfonate (JP15), EINECS
215-314-5, D01610

Molecular Formula: C7H7KO5S
Molecular Weight: 242.29 g/mol
Pharmacological class: Sedative Expectorant

Action: May enhance output of respiratory tract fluid by reducing adhesiveness and surface tension, thus facilitating removal of viscous mucus and making nonproductive coughs more productive and less frequent. Efficacy not well documented.

Indications Temporary relief of cough associated with respiratory tract infections and related conditions such as sinusitis, pharyngitis, bronchitis, and asthma when these conditions are complicated by tenacious mucus or mucus plugs and congestion; effective for productive as well as nonproductive cough, particularly dry, nonproductive cough that tends to injure mucous membranes of the air passages
).

Route/Dosage
Immediate-release Adults and Children (at least 12 yr): PO 200 to 400 mg q 4 hr (max, 2.4 g/day).
Children (6 to 12 yr): PO 100 to 200 mg q4 hr (max, 1.2 g/day).
Children (2 to 6 yr): PO 50 to 100 mg q 4 hr (max, 600 mg/day).
Children (6 mo to under 2 yr): PO Individualize dose, 25 to 50 mg q 4 hr (max, 300 mg/day).
Sustained- or Extended-release Adults and children (at least 12 yr): PO 575 mg to 1.2 g q 12 hr (max, 2.4 g/day).
Children (6 to 12 yr): PO 575 to 600 mg q 12 hr (max, 1.2 g/day).
Children (2 to 6 yr): PO 275.5 to 300 mg q 12 hr (max, 600 mg/day

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